台大心理系

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系所成員

系所師資

專任教授

賴文崧 Lai, Wen-Sung

職稱: 教授
研究領域: 生物心理學
E-Mail: Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它
辦公室/電話: S402/ 886-2-33663112
研究興趣:
The “LINE” (Laboratory of Integrated Neuroscience and Ethology) is a multi-disciplinary research laboratory which emphasizes the integrative understanding of the links between brain/mind and behaviors from multi-disciplinary approaches. Our current research interests mainly focus on 4 lines of studies. (1) To study mouse models of psychiatric disorders and the possible role of AKT1 and other schizophrenia candidate genes (e.g., NRG1 and DISC1) in the pathogenesis of schizophrenia. (2) To investigate higher cognitive functions and reward-based decision making in both mice and humans. (3) To study social neuroscience and the neural basis of social learning and memory using hamsters as a model. (4) Preclinical evaluation of potential drugs for the treatment of schizophrenia.
提供課程:
行為神經科學研究方法／生理心理學專題研究／犯罪、毒品與人性／生物分子交互作用之網絡
個人網站: http://www.psy.ntu.edu.tw/LINE/
經歷:
08/2011 – present：Adjunct Associate Professor, Graduate Institute of Brain and Mind Sciences, National Taiwan University
08/2006 – 07/2011：Assistant Professor, Department of Psychology, National Taiwan University
08/2011 – present：Question Drafters of National Examinations, Ministry of Examination, R.O.C.
09/2006 – present：Committee member of Institutional Animal Care and Use Committee, National Taiwan University, Taipei, Taiwan.
09/2009 – present：Committee member of Laboratory Animal Center of National Taiwan University, National Taiwan University, Taipei, Taiwan.
09/2007 – present：Committee member of Institutional Animal Care and Use Committee , National Cheng-Chi University, Taipei, Taiwan.
02/2009 – present：Committee member of Psychological Terms and Translation, National Academy for Educational Research
02/2009 – 08/2012：Committee member of Biopsychological Terms and Translation, National Institute for Compilation and Translation
2011：Review Committee of Generating Genetically Modified Mice/Rats Project, National Laboratory Animal Center, Taiwan
2010：Review Committee of Health Foods for the Prevention of Depression, Food and Drug Administration, Department of Health, Executive Yuan
2010：Review Committee of Non-formal Education Programs Accreditation Center, National Taiwan Normal University
07/01/96 - 06/01/98：Ensign Psychological Counselor, First Naval District Base, R.O.C. Navy
學術榮譽:
Marquis Who’s Who in the World 2012 (29th Edition), Marquis Who’s Who LLC., U.S.A.
Outstanding Teaching Award, College of Science, National Taiwan University, 2009,2010
Outstanding Teaching Award in General Knowledge Courses, National Taiwan University, 2009
Invited presenter, International Symposium on Schizophrenia: Focusing of Genes & Neurobiology, Taipei, Taiwan, 08/11/2007-08/12/2007
Hsien Wu & Daisy Yen Wu Memorial Scholarship Award, Cornell University, 2003
Olin Fellowship, Cornell University, 2002-2003
Taiwanese Bioscientists of America (TBA) Graduate Student Travel Awards, TBA symposium, Orlando, FL 2002 and San Diego, CA, U.S.A., 2001
Cornell Conference Transportation Awards, Graduate School, Cornell University, Ithaca, NY, U.S.A., July and November 2001
The Department of Psychology Graduate Student Award, Cornell University, Ithaca, NY, U.S.A., 2000
Governmental Fellowship for Ph.D. study: Cognitive neuroscience research, Ministry of Education, Taiwan, Republic of China (R.O.C.) 1998 - 2001

2014-2016：Planning Group Manager of France-Taiwan Frontiers of Science, Department of International Cooperation and Science Education, Ministry of Science and Technology, Taiwan.
06/10-13/2014：Chairman of Humanities and Social Sciences Section, The 7th France-Taiwan Frontiers of Science, Department of International Cooperation and Science Education, Ministry of Science and Technology, New Taipei city, Taiwan.
3/14-15/2014：Travel Award and Invited Speaker, The 9th Annual Meeting of Japanese Society of Schizophrenia Research (JSSR), Kyoto, Japan.
03/29-30/2014：Invited general participant, The 7th France-Taiwan Frontiers of Science – Taiwan FoS , Department of International Cooperation, National Science Council, New Taipei city, Taiwan.
2014：Short-term Visiting Scholars of Academia Sinica，Academia Sinica, Taipei, Taiwan
08/2013-07/2016：Distinguished Young Investigator Grant, Ministry of Science and Technology, Taiwan, Taipei, Taiwan.
12/12/2013：Invited speaker, 2013中華實驗動物學會學術研討會, Taipei, Taiwan. .
06/10-12/2013：Invited general participant, The 6th France-Taiwan Frontiers of Science, Bordeaux, France.
03/2013：Distinguished mentor in the Department of Psychology, National Taiwan University, Taipei, Taiwan.
03/23-24/2013：Invited general participant, The 6th France-Taiwan Frontiers of Science – Taiwan FoS, Department of International Cooperation, National Science Council, Taipei, Taiwan.
02/18/2013：Invited speaker, Symposium on Decision Science and Brain, Research Center for Mind, Brain, and Learning, National Cheng-Chi University, Taipei, Taiwan.
08/27/2011：Invited speaker, the 1st annual meeting of Taiwanese Society of Schizophrenia Research, Taipei, Taiwan.
08/20/2011：Invited speaker, International Symposium on Brain and Mind Sciences, Schizophrenia Research: Genes, Neurobiology, Cognitive Science and Clinical Service, Taipei, Taiwan.
2010：Distinguished Teaching Award, College of Science, National Taiwan University.
2009：Distinguished Teaching Award in General Knowledge Courses, National Taiwan University.
2009：Distinguished Teaching Award, College of Science, National Taiwan University.
11/26/2009：Invited speaker, 2009中華實驗動物學會第十屆學術研討會, Taipei, Taiwan.
08/15/2009-08/16/2009：Invited speaker, International Symposium on Brain and Mind Science, Pathogenesis Study of Schizophrenia: Genes, Neurobiology and Clinical Service, Taipei, Taiwan
Advisor of the Champion Group, 2008 High School Biological competition of Taipei city, Taipei, Taiwan.
08/11/2007-08/12/2007：Invited presenter, International Symposium on Schizophrenia: Focusing of Genes & Neurobiology, Taipei, Taiwan.
2003：Hsien Wu & Daisy Yen Wu Memorial Scholarship Award, Cornell University.
2002-2003：Olin Fellowship, Cornell University.
Taiwanese Bioscientists of America (TBA) Graduate Student Travel Awards, TBA symposium, Orlando, FL 2002 and San Diego, CA, U.S.A., 2001
2001：Cornell Conference Transportation Awards, Graduate School, Cornell University, Ithaca, NY, U.S.A.
2000：The Department of Psychology Graduate Student Award, Cornell University, Ithaca, NY, U.S.A.
1998 - 2001：Governmental Fellowship for Ph.D. study: Cognitive neuroscience research, Ministry of Education, Taiwan, Republic of China (R.O.C.)
學歷:
2003 美國康乃爾大學心理學博士
1996 國立政治大學心理學碩士
1997 國立政治大學心理學學士

期刊論文 Publications

Shen, C.L., Chou, T.L., Lai, W.S., Hsieh, M.H., Liu, C.C., Liu, C.M., Hwu, H.G.(2020) P50, N100, and P200 auditory sensory gating deficits in schizophrenia patients. Frontiers in Psychiatry, https://doi.org/10.3389/fpsyt.2020.00868. (SCI)

賴文崧。(2020)。您所不知道的心理學？開拓心智研究及精神疾病藥物研發的美麗「心」世界。台大校友雙月刊（NTU Alumni Bimonthly）, 第129期, 44-48。

賴文崧、羅達中(2020)。為絕症尋找「仙丹」-共濟失調症新藥研發與篩檢測試平台. 人文與社會科學簡訊（Humanities and Social Sciences Newsletter）, 21:2, 16-23, 2020

Luo, D.Z.#, Chang, C.Y.#, Huang, T.R., Studer, V., Wang, T.W., Lai, W.S.* (2020). Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models. Scientific Reports, 10:647.(SCI)

Pei, J.C.#, Hung, Wei-Li#, Lin, B.X., Shih, M.H., Lu, L.Y., Luo, D.Z., Tai, H.C., Studer, V., Min, M.Y., Lai, W.S.* (2019). Therapeutic potential and underlying mechanism of sarcosine (N-methylglycine) in N-methyl-D-aspartate (NMDA) receptor hypofunction models of schizophrenia. Journal of Psychopharmacology, 33(10), 1288-1302. (SCI)

Liu, H.H.#, Hwang, Y.D., Hsieh, M.H., Hsu, Y.F.*, Lai, W.S.* (2017). Misfortune may be a blessing in disguise: Fairness perception and emotion modulate decision making. Psychophysiology, 54(8), 1163-1179. (doi:10.1111/psyp.12870).

Pan, M.K., Kuo, S.H., Tai, C.H., Liou, J.Y., Pei, Ju-Chun, Chang, C.Y., Wang, Y.M., Liu, W.C., Wang, T.R., Lai, W.S., Kuo, C.C.* (2016). Neuronal codes outweigh circuitry oscillations in parkinsonian motor control. Journal of Clinical Investigation, 126(12), 4516-4526, 2016 (doi:10.1172/JCI88170).

Chang, C.Y., Chen, Y.W., Wang, T.W., Lai, W.S.*(2016). AKTing up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions. Scientific Reports, 6:33095, (doi:10.1038/srep33095).

Huang, C.W., Hong, T.W., Wang, Y.J., Chen, K.C., Pei, J.C., Chuang, T.Y., Lai, W.S., Tsai, S.H., Chu, R., Chen, W.C., Sheen, L.Y., Takahashi, S., Ding. S.T., Shen, T.L.* (2016). Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model. BMC Complementary and Alternative Medicine, 16(1), 310, (doi: 10.1186/s12906-016-1278-7 ).

Yu, W.C., Liu, C.Y., Lai, W.S.* (2016). Repeated, intermittent social defeat across the entire juvenile period resulted in behavioral, physiological, hormonal, immunological, and neurochemical alterations in young adult male golden hamsters. Frontiers in Behavioral Neuroscience, 10:110, (doi: 10.3389/fnbeh.2016.00110).

Yeh, C.W., Yeh, S.H.H., Shie, F.S., Lai, W.S., Liu, H.K., Tzeng, T.T., Tsay, H.J., Shiao, Y.J. (2015). Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiology of aging, 36(11), 2984-2994. (doi:10.1016/j.neurobiolaging.2015.07.022).

Liu, H.H., Hsieh, M.H., Hsu, Y.F.*, Lai, W.S.*(2015). Effects of affective arousal on choice behavior, reward prediction errors, and feedback-related negativities in human reward-based decision making. Frontiers in Psychology, 6:592,(doi:10.3389/fpsyg.2015.0059).

Hung, C.H., Pei, J.C., Luo, D.Z., Chen, C., Chen, Y.W., Lai, W.S.*(2015). Investigation of epistatic interactions between Akt1 and neuregulin 1 genes in the regulation of behavioral phenotypes and social functions in genetic mouse models of schizophrenia. Frontiers in Behavioral Neuroscience, 8, 455. (doi: 10.3389/fnbeh.2014.00455).

Li, C.T.#, Lai, W.S.#, Liu, C.M., Hsu, Y.F.*,(2014). Inferring reward prediction errors in patients with schizophrenia: a dynamic reward task for reinforcement learning. Frontiers in Psychology, 5: 1282, (doi:10.3389/fpsyg.2014.01282).

Pan, M.K., Tai, C.H., Liu, W.C., Pei, J.C., Lai, W.S., Kuo, C.C.* (2014). Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. Journal of Clinical Investigation, 124(10), 4629-4641. (doi: 10.1172/JCI75587).

Li, C.T., Lai, W.S.*, Hsu, Y.F.* (2014). Using a reinforcement learning model and Bayes factors to study gender differences and personality correlations in reward prediction errors (以增強學習模型與貝氏因子探討酬賞預測誤差的男女差異及性格相關). The Chinese Journal of Psychology (中華心理學刊), 56(4), 453-466. (doi: 10.6129/CJP.20140411).

Pei, J.C., Liu, C.M., Lai, W.S.*(2014). Distinct phenotypes of new transmembrane-domain neuregulin 1 mutant mice and the rescue effects of valproate on the observed schizophrenia-related cognitive deficits. Frontiers in Behavioral Neuroscience, 8: 126. (doi: 10.3389/fnbeh.2014.00126).

Chen, Y.W., Kao, H.Y., Min, M.Y., Lai, W.S.*(2014). A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis. Schizophrenia Bulletin, 40(2), 388-398. (doi: 10.1093/schbul/sbt031)

Lai, W.S.*, Yu, W.C., Liu, C.Y., Kuo, M.T., Huang, C.H. (2014). A new method for studying social eavesdropping using male golden hamsters. Physiology & Behavior, 128, 202-211. (doi: 10.1016/j.physbeh.2014.01.029 ).

Lai, W.S.*, Chang, C.Y.#, Wong, W.R.#, Pei, J.C.#, Chen, Y.S., Hung, W.L. (2014). Assessing schizophrenia-relevant cognitive and social deficits in mice: a selection of mouse behavioral tasks and potential therapeutic compounds. Current Pharmaceutical Design, 20(32), 5139-5150. (doi: 10.2174/1381612819666140110122750).

Juan, L.W., Laio, C.C. Lai, W.S., Chang, C.Y., Pei, J.C., Wong, W.R., Liu, C.M., Hwu, H.G., Lee, L.J.* (2014). Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain. Brain Structure and Function, 219(4), 1417-1431. (doi: 10.1007/s00429-013-0577-8).

Liu, Y.H., Lai, W.S., Tsay, H.J., Wang, T.W., Yu, J.Y.*(2013). Effects of maternal immune activation on adult neurogenesis in the subventricular zone-olfactory bulb pathway and olfactory discrimination. Schizophrenia Research, 151, 1-11, 2013 (doi: 10.1016/j.schres.2013.09.007).

Hao, C.W., Lai, W.S., Ho, C.T., Sheen, L.Y. (2013). Antidepressant-like effect of lemon essential oil is through a modulation in the levels of norepinephrine, dopamine, and serotonin in mice: use of the tail suspension test. Journal of Functional Foods, 5, 370-379..

Lai, W.S.* Towards an understanding of the biology of the mind: Insights from Akt1 mouse model of schizophrenia. Proceedings of the Taiwanese Society of Schizophrenia Research, 24-32, 2012 (Invited article).

Chen, Y.C., Chen, Y.W., Hus, Y.F., Chang, W.T., Hsiao C.K., Min, M.Y., Lai, W.S.* AKT1 deficiency modulates reward learning and reward prediction error in Mice. Genes, Brain and Behavior, 11, 157-169, 2012 (SCI, 10/49 in Behavioral Sciences).

Ono, Y., Lin, H.C., Tzen, K.Y., Chen, H.H., Yang, P.F., Lai, W.S., Chen, J.H., Onozuka, M., Yen, C.T.* Active coping with stress suppresses glucose metabolism in the rat hypothalamus. Stress, 15(2), 207-217, 2012 (SCI, 12/49 in Behavioral Sciences).

Chen, Y.W., Lai, W.S.* Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics. Neuroscience, 174, 178-189, 2011 (The cover art of this issue; SCI, 103/251 in Neuroscience).

Kuo, M.T., Jong, D.S., Lai, W.S.* A biological validation procedure for the measurements of fecal outputs and fecal cortisol metabolites in male Syrian hamsters. The Chinese Journal of Physiology, 54(5), 45-53, 2011 (SCI, 65/81 in Physiology, top 1 Physiological journal in Taiwan).

Huang, C.H., Kuo, M.T., Lai, W.S.* Characterization of behavioural responses in different test contexts after a single social defeat in male golden hamsters (Mesocricetus auratus). Behavioural Processes, 86, 94-101, 2011 (SCI, 46/152 in Zoology).

Chen, Y.C., Lai, W.S.* Behavioural phenotyping of dopamine transporter knockdown mice using local small interference RNA. Behavioural Brain Research, 214(2), 475-479, 2010 (SCI, 14/49 in Behavioral Sciences).

Liao, C.C., Chen, R.F., Lai, W.S., Lin, R.C.S, Yen, C.T.* Distribution of large terminal inputs from the primary and secondary somatosensory cortices to the dorsal thalamus in the rodent. Journal of Comparative Neurology, 518(13), 2592-2611, 2010 (SCI, 5/152 in Zoology).

Stark, K.L., Xu, B., Bagchi, A., Lai, W.S., Liu, H., Hsu, R., Wan, X., Pavlidis, P., Mills, A.A., Karayiorgou, M., Gogos, J.A.* Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nature Genetics, 40(6), 751-760, 2008 (SCI). Hsu, R., Woodroffe, A., Lai, W.S., Cook, M.N., Mukai, J., Dunning, J.P., Swanson, D.J., Roos, J.L., Abecasis, G.R., Karayiorgou, M., Gogos, J.A.* Nogo Receptor 1 (RTN4R) as a Candidate Gene for Schizophrenia: Analysis Using Human and Mouse Genetic Approaches. PLoS ONE. 2007 Nov 28;2(11):e1234 (SCI, 8/55 in multidisciplinary Sciences).

Lai, W.S., Xu, B., Westphal, K.G.C., Paterlini, M., Olivier, B., Pavlidis, P., Karayriorgou, M., & Gogos, J.A.* Akt1 deficiency predisposes to abnormalities in prefrontal cortex functioning. Proceedings of the National Academy of Sciences (PNAS), 103, 16906-16911, 2006 (SCI).

Lai, W.S., Ramiro, L.R., Yu, H.A. & Johnston, R.E.* Recognition of familiar individuals in golden hamsters: a new method and functional neuroanatomy. Journal of Neuroscience, 25(49), 11239-11247, 2005 (SCI).

Paterlini, M., Zakharenko, S.S., Lai, W.S., Qin, J., Zhang, H., Mukai, J., Westphal K.G.C., Olivier, B., Sulzer, D., Pavlidis, P., Siegelbaum, S.A., Karayiorgou, M., & Gogos, J.A.* Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nature Neuroscience, 8, 1586-1594, 2005 (SCI, 6/251 in Neuroscience).

Lai, W.S., Chen, A., & Johnston, R.E.* Patterns of neural activation associated with exposure to odors from a familiar winner in male golden hamsters. Hormones and Behavior, 46(3), 319-329, 2004 (SCI).

Mukai, J., Liu, H., Burt, R.A., Swor, D.E., Lai, W.S., Karayiorgou, M., & Gogos, J.A.* Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nature Genetics, 36, 725-731, 2004 (SCI).

Lai, W.S. & Johnston, R.E.* Individual recognition after fighting by golden hamsters: a new method. Physiology and Behavior, 76(2), 225-239, 2002 (SCI).

Liao, R.M., Lai, W.S., & Lin, J.Y.* The role of catecholamines in retention performance of a partially baited radial eight-arm maze for rats. The Chinese Journal of Physiology, 45(4), 177-185, 2002 (SCI).

Lai, W.S., Chen, A., Yu, H.A., & Johnston, R.E.* Olfactory memory and individual recognition in golden hamsters. Society for Behavioral Neuroendocrinology Annual Meeting. Hormones and Behavior, 46(1), 115, 2004 (SCI).

Lai, W.S., Chen, A., & Johnston, R.E.* Aggression and memory for individuals in golden hamsters: functional neuroanatomy and role of protein synthesis. Society for Behavioral Neuroendocrinology Annual Meeting. Hormones and Behavior, 41(4), 477, 2002 (SCI).

專書專章 Books/Chapters

Pei, J.C., Liu, C.M., Lai, W.S. (2015). Distinct phenotypes of new transmembrane-domain neuregulin 1 mutant mice and the rescue effects of valproate on the observed schizophrenia-related cognitive deficits. In Stuchlik, A. & Sumiyoshi, T. (Eds). Cognitive Deﬁcits in Schizophrenia and other Neuropsychiatric Disorders: Convergence of Preclinical and Clinical Evidence (pp. 88-107). Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-679-1 (Frontiers E-book 2015: https://www.academia.edu/19611034/Frontiers_E-book_2015).

Wen-Sung Lai, 2009. To beat or not to beat? Individual recognition and social memory in golden hamsters (ISBN 978-3-8383-1501-0). Lambert Academic Publishing, Köln, Germany.

研討會論文 Conference Presentations

Liu, H.H., Hsieh, M.H., Hsu, Y.F., Lai, W.S. Effects of affective arousal on choice behavior, reward-prediction error, and feedback-related negativity in human reward-based decision making. The Annual Meeting of the Society for Neuroscience (SfN), Oct. 17-21, 2015, Chicago, Illinois, U.S.A.

Chang, C.Y., Luo, D.Z., Wang, T.W., Studer, V., Lai, W.S. The effect of lithium on the alleviation of AKT1-related neuromorphological and behavioral deficits in P19 cell line, primary cell culture, and Akt1 mutant mice. The Annual Meeting of the Society for Neuroscience (SfN), Oct. 17-21, 2015, Chicago, Illinois, U.S.A.

Chen, C., Liu, Y.W., Lee, T.P., Lai, W.S. The role of Akt1 in the regulation of behavioral and electrophysiological responses in reward-based decision making in mice. The Annual Meeting of the Society for Neuroscience (SfN), Oct. 17-21, 2015, Chicago, Illinois, U.S.A.

Liu, C.Y., Yu, W.C., Chang, C.Y., Lai, W.S. Investigation of neural activity during social eavesdropping in male golden hamsters using c-Fos immunohistochemistry and local field potential recording. The Annual Meeting of the Society for Social Neuroscience (S4SN), Oct. 16, 2015, Chicago, Illinois, U.S.A.

Lai, W.S., Chen, C., Liu, H.H., Liu, Y.W., Li, C.T., Chen, Y.C., Liu, C.M., Hsu, Y.F. From reward prediction error to dopamine hypothesis of psychosis: Insights from Akt1 mutant mice and schizophrenic patients. 2015 Annual Meeting of International Behavioral Neuroscience Society, June 2-7, 2015, Victoria, British Columbia, Canada. (Invited speaker and symposium organizer)

Liu, C.Y., Yu, W.C., Chang, C.Y., Lai, W.S. Investigation of behavioral response and neural activity underlying social eavesdropping in male golden hamsters. The Annual Meeting of the Society for Social Neuroscience (S4SN), Nov. 13-14, 2014, Washington D.C., U.S.A.

Wong, W.R., Hung, C.H., Lai, W.S. The involvement of Akt1 in the modulation of immune responses and behavioral consequences in Akt1 deficient mice after neonatal polyI:C challenge. The 44th Annual Meeting of the Society for Neuroscience, Nov. 15-19, 2014, Washington D.C., U.S.A.

Hung, W.L., Lai. W.S. Evaluation of the effect of sarcosine, an endogenous glycine transporter 1 inhibitor, on behavioral performance and the glutamate hypothesis of schizophrenia in mice The 44th Annual Meeting of the Society for Neuroscience, Nov. 15-19, 2014, Washington D.C., U.S.A.

Liu, Y.W., Chen, C., Lai, W.S. The role of striatal subregions in reinforcement learning process and reward prediction error using excitotoxic lesion in male C57/Bl6 mice. The 44th Annual Meeting of the Society for Neuroscience, Nov. 15-19, 2014, Washington D.C., U.S.A.

Liu, C.Y., Yu, W.C., Chang, C.Y., Lai, W.S. Behavioral response and functional neuroanatomy of male golden hamsters during social eavesdropping. The 44th Annual Meeting of the Society for Neuroscience, Nov. 15-19, 2014, Washington D.C., U.S.A.

Chang, C.Y., Luo, D.Z., Wang, T.W., Lai, W.S. The effect of lithium on the alleviation of neuromorphological and behavioral deficits in AKT-promoted P19 embryonal carcinoma cells and Akt1 mouse model of schizophrenia. The 44th Annual Meeting of the Society for Neuroscience, Nov. 15-19, 2014, Washington D.C., U.S.A.

Lai, W.S. From reward prediction error to dopamine hypothesis of psychosis: Insights from Akt1 mutant mice and schizophrenic patients. The 9th Annual Meeting of Japanese Society of Schizophrenia Research (JSSR), Kyoto, Japan, 3/14-15/2014.

Liu, H.H., Chien, Y.L., Lai. W.S., Tseng, Y.L. Investigation of EEG cross-frequency coupling in statistical learning of natural facial images. The 37th Annual Meeting of the Japan Neuroscience Society, September 11-13, 2014, Yokohama, Japan.

Luo, D.Z., Chang, C.Y., Wang, T.W., Lai. W.S. Evaluating the therapeutic potential of lithium on the alleviation of neuromarphological and behavioral deficits in AKT-promoted P19 embryonal carcinoma cells and Akt1 mouse model of schizophrenia The 37th Annual Meeting of the Japan Neuroscience Society, September 11-13, 2014, Yokohama, Japan.

Chen, C., Liu, Y.W., Lai, W.S. The role of Akt1, a schizophrenia susceptibility gene, in the regulation of motivational salience and reward-based choices in mice. The 37th Annual Meeting of the Japan Neuroscience Society, September 11-13, 2014, Yokohama, Japan.

Wong, W.R. Huang, C.H., Lai, W.S. The effect of Akt1 deficiency in immune response and adult behavioral consequences in mice with neonatal poly(I:C) exposure. The 12th annual meeting of the Molecular and Cellular Cognition Society, Nov.7-8, 2013, San Diego, CA., U.S.A.

Luo, D.Z., Hwang, T.J., Yen, R.F., Chang, C.Y., Lai, W.S. Age-specific effect of Akt1 on the regulation of striatal dopamine D2 receptor activity in Akt1 mutant mouse model of schizophrenia using MicroPET scan. The 12th annual meeting of the Molecular and Cellular Cognition Society, Nov.7-8, San Diego, CA., U.S.A.

Chang, C.Y., Chen, Y.W., Lai, W.S. Akt1 deficiency modulates GABAergic transmission and hippocampal-dependent cognitive functions in mice. The 43rd Annual Meeting of the Society for Neuroscience, Nov. 9-13, 2013, San Diego, CA, U.S.A.

Wong, W.R., Huang, C.H., Lai, W.S. Behavioral phenotyping of adult Akt1 deficient mice after experiencing neonatal poly(I:C) immune challenge. The 43rd Annual Meeting of the Society for Neuroscience, Nov. 9-13, 2013, San Diego, CA, U.S.A.

Luo, D.Z., Hwang, T.J., Yen, R.F., Chang, C.Y., Lai, W.S. MicroPET imaging reveals alterations of basal and methamphetamine-induced striatal dopamine D2 receptor activity in adult but not adolescent Akt1 deficient male mice. The 43rd Annual Meeting of the Society for Neuroscience, Nov. 9-13, 2013, San Diego, CA, U.S.A.

Pei, J.C., Huang, C.H., Chen, C., Wong, W.R., Lai, W.S.* Phenotypic characterization of new neuregulin 1 transmembrane-domain mutant mice and evaluation of the rescue effects of valproate on the observed hippocampal cognitive deficits in these neuregulin 1-deficient mice. Development, Function & Disease of Neural Circuits, Cold Spring Harbor Conferences Asia, Oct. 21-25, 2013, Su-Zhou, China.

Pei, J.C., Chen, C, Chen, Y.W., Lai, W.S. A sex- and hippocampal- specific role of neuregulin 1 in the regulation of hippocampus-dependent cognitive function and GABAergic interneurons in neuregulin 1 mutant mice. The 36th Annual Meeting of the Japan Neuroscience Society, June 20-23, 2013, Kyoto, Japan.

Chang, C.Y., Chen, Y.W., Wang, T.W., Lai, W.S. The emerging role of AKT1 in the modulation of parvalbumin-containing GABAergic interneurons and GABA type A receptors both in vitro and in vivo: implication for the pathogenesis of schizophrenia. The 36th Annual Meeting of the Japan Neuroscience Society, June 20-23, 2013, Kyoto, Japan.

Wong, W.R., Huang, C.H., Lai, W.S. Investigating gene-environment interactions in schizophrenia-related phenotypes using neonatal immune challenge in Akt1 mutant mice as a model. The 36th Annual Meeting of the Japan Neuroscience Society, June 20-23, 2013, Kyoto, Japan.
Chen, Y.W., Kao, H.Y., Min, M.Y., Lai, W.S. A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: potential implications in schizophrenia and methamphetamine use disorders. The 36th Annual Meeting of the Japan Neuroscience Society, June 20-23, 2013, Kyoto, Japan.

Chen, Y.W., Hwang, T.J., Kao, H.Y., Min, M.Y., Lai, W.S. A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: potential implications in schizophrenia and methamphetamine use disorders. The 11th Annual Molecular and Cellular Cognition Society meeting, Oct. 11-12, 2012, New Orleans, LA, U.S.A.

Li, C.T., Liu, C.M., Chen, Y.C., Hsu, Y.F., Lai, W.S. From reward prediction error to dopamine hypothesis of psychosis: Insights from Akt1 mutant mice and schizophrenia patients. The 11th Annual Molecular and Cellular Cognition Society meeting, Oct. 11-12, 2012, New Orleans, LA, U.S.A.

Pei, J.C., Chen, C., Chen, Y.W., Huang, C.H., Lai, W.S. Sex-specific hippocampus-dependent cognitive deficits and alternations of hippocampal GABAergic interneurons in neuregulin 1 haploinsufficient mice. The 11th Annual Molecular and Cellular Cognition Society meeting, Oct. 11-12, 2012, New Orleans, LA, U.S.A.

Chang, C.Y., Chen, Y.W., Wang, T.W., Lai, W.S. The emerging role of AKT1 in the modulation of parvalbumin-containing GABAergic interneurons and GABA type A receptors: implication for the pathogenesis of schizophrenia. The 11th Annual Molecular and Cellular Cognition Society meeting, Oct. 11-12, 2012, New Orleans, LA, U.S.A.

Chen, Y.W., Kao, H.Y., Min, M.Y., Lai, W.S. Sex-specific effect of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity. The 42nd Annual Meeting of the Society for Neuroscience, Oct. 13-17, 2012, New Orleans, LA, U.S.A.

Pei, J.C., Chen, Y.W., Huang, C.H., Lai, W.S. Sex-specific alterations of hippocampus-related cognitive functions and the expression of GABAergic interneurons in neuregulin 1 (NRG1) deficient mice. The 42nd Annual Meeting of the Society for Neuroscience, Oct. 13-17, 2012, New Orleans, LA, U.S.A.

Chang, C.Y., Chen, Y.W., Wang, T.W., Lai, W.S. AKT1 modulates the expression and function of GABAergic interneurons and GABA type A receptors in vitro and in vivo. The 42nd Annual Meeting of the Society for Neuroscience, Oct. 13-17, 2012, New Orleans, LA, U.S.A.

Chen, Y.W., Chen, Y.S., Lai, W.S. AKTing up in Hippocampus - Examination of Hippocampus-related Cognitive Function and Hippocampal Neuromorphology in Akt1 Knockout Mice. The 10th Annual Molecular and Cellular Cognition Society meeting, Nov. 11, 2011, Washington DC, U.S.A.

Chen, Y.S., Chen, Y.W., Chen, Y.C., Lai, W.S. Attentional performance of AKT1 mutant mice in the five-choice serial reaction time task. The 10th Annual Molecular and Cellular Cognition Society meeting, Nov. 11, 2011, Washington DC, U.S.A.

Pei, J.C., Chen, Y.W., Chen, Y.C., Huang, C.H., Jhang, S.R., Lai, W.S. Alterations of hippocampus-related cognitive functions and the expression of GABAergic markers in neuregulin 1 (NRG1) deficient mice. The 10th Annual Molecular and Cellular Cognition Society meeting, Nov. 11, 2011, Washington DC, U.S.A.

Chen, Y.W., Chen, Y.S., Lai, W.S. The deficiency of AKT1 results in the reduction of hippocampus-related cognitive performance and hippocampal neuromorphology in mice. The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Chang, C.Y., Chen, Y.W., Wang, T.W., Lai, W.S. AKT1 modulates the severity of pentylenetetrazol-induced convulsion and the function of GABAergic interneurons. The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Yu, W.C., Chang, C.Y., Kuo, M.T., Lai, W.S. An investigation of social learning and its functional neuroanatomy in male Syrian hamsters. The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Pei, J.C., Chen, Y.W., Chen, Y.C., Huang, C.H., Jhang, S.R., Lai, W.S. The deficiency of NRG1 resulted in the alterations of cognitive and hippocampus-related functions in mice. The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Lee, L.J., Juan, L.W., Liao, C.C., Wong, W.R., Pei, J.C., Lai, W.S. Morphological, physiological and behavioral characterizations of Disc1 mutant mice. The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Huang, C.H., Chen, Y.W., Pei, J.C., Lai, W.S. Characterizations of behavioral and cognitive functions in NRG1-AKT1 single and double mutant mice The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Chen, Y.S., Chen, Y.W., Chen, Y.C., Lai, W.S. Evaluation of attentional functions in AKT1 mouse model of schizophrenia using the five-choice serial reaction time task The 41st Annual Meeting of the Society for Neuroscience, Nov. 12-16, 2011, Washington, D.C., U.S.A.

Chen, Y.W., Chang, W.T., Lai, W.S. Akt1 deficiency causes alterations in hippocampal neuromorphology and hippocampus-dependent cognitive function. The 34th Annual Meeting of the Japan Neuroscience Society, Sep. 14-17, 2011, Yokohama, Japan.

Yu, W.C., Chang, C.Y., Kuo, M.T., Lai, W.S. The behavioral consequence and functional neuroanatomy of social learning in male Syrian hamsters. The 34th Annual Meeting of the Japan Neuroscience Society, Sep. 14-17, 2011, Yokohama, Japan.

Chen, Y.S., Chen, Y.W., Chen, Y.C., Lai, W.S. The application of the five-choice serial reaction time task in animal models of schizophrenia: using AKT1 knockout mice as an example. The 34th Annual Meeting of the Japan Neuroscience Society, Sep. 14-17, 2011, Yokohama, Japan.

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賴文崧 Lai, Wen-Sung